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Proceedings Paper

Spectrally constrained NIR tomography for breast imaging: simulations and clinical results
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Paper Abstract

A multi-spectral direct chromophore and scattering reconstruction for frequency domain NIR tomography has been implemented using constraints of the known molar spectra of the chromophores and a Mie theory approximation for scattering. This was tested in a tumor-simulating phantom containing an inclusion with higher hemoglobin, lower oxygenation and contrast in scatter. The recovered images were quantitatively accurate and showed substantial improvement over existing methods; and in addition, showed robust results tested for up to 5% noise in amplitude and phase measurements. When applied to a clinical subject with fibrocystic disease, the tumor was visible in hemoglobin and water, but no decrease in oxygenation was observed, making oxygen saturation, a potential diagnostic indicator.

Paper Details

Date Published: 28 April 2005
PDF: 8 pages
Proc. SPIE 5693, Optical Tomography and Spectroscopy of Tissue VI, (28 April 2005); doi: 10.1117/12.590576
Show Author Affiliations
Subhadra Srinivasan, Dartmouth College (United States)
Brian W. Pogue, Dartmouth College (United States)
Shudong Jiang, Dartmouth College (United States)
Hamid Dehghani, Dartmouth College (United States)
Keith D. Paulsen, Dartmouth College (United States)

Published in SPIE Proceedings Vol. 5693:
Optical Tomography and Spectroscopy of Tissue VI
Britton Chance; Robert R. Alfano; Bruce J. Tromberg; Mamoru Tamura; Eva M. Sevick-Muraca, Editor(s)

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