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Proceedings Paper

Detection limit improvement of surface plasmon resonance based biosensors using statistical hypothesis testing
Author(s): Anne Barnett; Ewa M. Goldys; Konrad Dybek
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Paper Abstract

We propose a new approach to improving the resolution of a Surface Plasmon Resonance (SPR) based biosensing system through the use of the statistical technique of hypothesis testing. Simulated SPR reflectance curves at the wavelength of 632.8 nm in the Kretschmann configuration were generated. Detector specifications were taken from Ames Photonics CMOS Larry-CCD 1024 array detector with a total integration time of 100s and a noise amplitude relative to signal σ = 3 × 10-6. We were able to achieve the detection limit of the refractive index difference with respect to water of Δn = 4 × 10-8 with 95 % significance level.

Paper Details

Date Published: 31 March 2005
PDF: 8 pages
Proc. SPIE 5703, Plasmonics in Biology and Medicine II, (31 March 2005); doi: 10.1117/12.590218
Show Author Affiliations
Anne Barnett, Macquarie Univ. (Australia)
Ewa M. Goldys, Macquarie Univ. (Australia)
Konrad Dybek, Macquarie Univ. (Australia)

Published in SPIE Proceedings Vol. 5703:
Plasmonics in Biology and Medicine II
Tuan Vo-Dinh; Joseph R. Lakowicz; Zygmunt K. Gryczynski, Editor(s)

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