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Proceedings Paper

Float genetic algorithm for determination of particle size distribution and refractive index in polarized LSS
Author(s): Yong Deng; Rui Hu; Qingming Luo; Qiang Lu
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Paper Abstract

Polarized light scattering spectroscopy (LSS) is sensitive to the cell nuclear morphological changes in the various forms of epithelial dysplasia. Extensive studies illustrate it is a promising in situ technique to detect precancerous and early cancerous changes in the epithelial tissue. To determine the density and size distribution of cell nuclei with spectra, generally, Mie theory-based inverse model is adopted. This model is of multiple parameters, multiple extreme values and nonlinear. The determination of all unknown parameters needs to solve a nonlinear inverse problem. Other than least-square fitting used by previous studies, in this paper, we developed a novel method - float genetic algorithm (FGA) to determine the particle size distribution and refractive index for LSS. Our results showed that, relative errors of three estimated statistical quantities: diameter, standard deviation and refractive index are less than 5% for different additive Gauss noise levels with 70 iteration epochs. The errors gradually decrease with iteration epoch increases. Moreover, comparing with Newton-type iteration method coupled with a Marquardt-Tikhanov regularization scheme, FGA avoids the problems of local extreme value and selection of initial value and regularization parameters, thus obtains the advantages of high precision, stability and robustness.

Paper Details

Date Published: 28 April 2005
PDF: 7 pages
Proc. SPIE 5693, Optical Tomography and Spectroscopy of Tissue VI, (28 April 2005); doi: 10.1117/12.589583
Show Author Affiliations
Yong Deng, Huazhong Univ. of Science and Technology (China)
Rui Hu, Huazhong Univ. of Science and Technology (China)
Qingming Luo, Huazhong Univ. of Science and Technology (China)
Qiang Lu, Huazhong Univ. of Science and Technology (China)


Published in SPIE Proceedings Vol. 5693:
Optical Tomography and Spectroscopy of Tissue VI
Britton Chance; Robert R. Alfano; Bruce J. Tromberg; Mamoru Tamura; Eva M. Sevick-Muraca, Editor(s)

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