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Proceedings Paper

Spectroscopic study of tetracycline-lanthanides complexes for biomedical applications
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Paper Abstract

Compared with the traditional organic fluorescent materials, the lanthanide coordination compounds have a large variety of applications, for example glucose sensing, based on the luminescence enhancement of a lanthanide-tetracycline complex due to enzymatically generated H2O2 at physiological glucose concentrations. It is known that the fluorescence is based on the energy-transfer from the ligand to the central lanthanide ion. The aim of this work was to study the optical properties of Europium, Erbium, Ytterbium, Holmium, Terbium and Neodymium tetracycline complexes. An increase in europium emission band was observed for the first time, with addition of urea peroxide in the solution. This method works at neutral pH and the luminescence was detected at visible lanthanides luminescence after a 10 min. incubation time of the samples.

Paper Details

Date Published: 4 April 2005
PDF: 7 pages
Proc. SPIE 5704, Genetically Engineered and Optical Probes for Biomedical Applications III, (4 April 2005); doi: 10.1117/12.588773
Show Author Affiliations
Lilia Coronato Courrol, Tecnologia de Sao Paulo (Brazil)
Flavia Rodrigues de Oliveira Silva, Tecnologia de Sao Paulo (Brazil)
Luis Vicente Gomes Tarelho, IPEN/CNEN (Brazil)
Laercio Gomes, IPEN/CNEN (Brazil)
Nilson Dias Vieira Jr., IPEN/CNEN (Brazil)

Published in SPIE Proceedings Vol. 5704:
Genetically Engineered and Optical Probes for Biomedical Applications III
Darryl J. Bornhop; Samuel I. Achilefu; Ramesh Raghavachari; Alexander P. Savitsky, Editor(s)

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