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Proceedings Paper

Ultrasound-tagged light assessment of osteoporosis
Author(s): Aner Lev; Evgeni Rubanov; Bruno Sfez; Shraga Shany; Joseph Foldes
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Paper Abstract

There have been several attempts to detect bone structural changes using optical techniques. H.G. Eberle et al. have used ultrafast optical techniques on the finger in trans-illumination and have shown an excellent correlation between their measurements of the scattering coefficient and bone mineral density obtained using dual X-ray absorption (DXA) imaging. Encouraged by these results, we have developed a system based on the combination of cw laser light and low-frequency ultrasound to probe the bone structure. The physical principle of this system is the detection of laser light diffusing in the bone tissue modulated ("tagged") by a low-frequency ultrasound pulse, which allows a local measurement of the attenuation coefficient. The basic assumption of the technique is that the main factor of attenuation changes in the bone of elderly patients is a scattering change due to osteoporosis, and therefore attenuation measurements directly reflect the scattering properties of the bone. We present a preliminary series of clinical experiments showing that this technique allows determining the bone scattering modification inside the trabecular bone. In this series of clinical experiments, the scattering coefficient determined using the optical technique is compared with the bone mineral density obtained using dual X-ray absorption in a group of 9 patients. A correlation of 0.84 (p=0.05) was found, showing the potential of this technique for the assessment of osteoporosis.

Paper Details

Date Published: 1 April 2005
PDF: 8 pages
Proc. SPIE 5692, Advanced Biomedical and Clinical Diagnostic Systems III, (1 April 2005); doi: 10.1117/12.588553
Show Author Affiliations
Aner Lev, Soreq Nuclear Research Ctr. (Israel)
Evgeni Rubanov, Soreq Nuclear Research Ctr. (Israel)
Bruno Sfez, Soreq Nuclear Research Ctr. (Israel)
Shraga Shany, Soroka Hospital (Israel)
Joseph Foldes, Hadassah Hospital (Israel)

Published in SPIE Proceedings Vol. 5692:
Advanced Biomedical and Clinical Diagnostic Systems III
Tuan Vo-Dinh; Warren S. Grundfest M.D.; David A. Benaron M.D.; Gerald E. Cohn, Editor(s)

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