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Proceedings Paper

Birefringence of healthy in vivo primate RNFL with high sensitivity PS-OCT
Author(s): Nathaniel Joseph Kemp; Haitham N. Zaatari; Jesung Park; Thomas E. Milner; Henry Grady Rylander III
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Paper Abstract

Form-birefringent properties of the retinal nerve fiber layer (RNFL) have become increasingly important as investigators strive to provide an improved methodology for glaucoma diagnosis. Techniques such as scanning laser polarimetry (SLP) and polarization-sensitive optical coherence tomography (PS-OCT) are two approaches which directly assess RNFL neurotubules, the sub-cellular structures responsible for form-birefringence and axoplasmic transport in retinal ganglion cell axons. We present a novel algorithm for enhancing the sensitivity of PS-OCT. Enhanced polarization-sensitive OCT (EPS-OCT) is capable of detecting small transformations in polarization typically experienced by light propagating through the thin and weakly birefringent primate RNFL. We report birefringence and nerve fiber orientation measurements for the peripapillary region in healthy in vivo primate RNFL and discuss the implications of the enhanced-sensitivity approach on noninvasive quantification of form-birefringence in glaucoma diagnostics.

Paper Details

Date Published: 18 April 2005
PDF: 12 pages
Proc. SPIE 5688, Ophthalmic Technologies XV, (18 April 2005); doi: 10.1117/12.588047
Show Author Affiliations
Nathaniel Joseph Kemp, Univ. of Texas/Austin (United States)
Haitham N. Zaatari, Univ. of Texas/Austin (United States)
Jesung Park, Univ. of Texas/Austin (United States)
Thomas E. Milner, Univ. of Texas/Austin (United States)
Henry Grady Rylander III, Univ. of Texas/Austin (United States)

Published in SPIE Proceedings Vol. 5688:
Ophthalmic Technologies XV
Fabrice Manns; Bruce E. Stuck; Michael Belkin M.D.; Per G. Söderberg; Arthur Ho, Editor(s)

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