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Proceedings Paper

Optical investigations of metronidazolum action on the cell membranes and proteins
Author(s): Era B. Popyhova; Pavel E. Kuznetsov; Svetlana M. Rogacheva; Konstantin I. Evlakov; Sergey A. Tolmachev; Machammad S. Kupadze
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Paper Abstract

Photometric and fluorescence methods have been used for investigation of the drug 1-(2'hydroxiethil)-2-methil-5nitroimidazole (metronidazolum) action on the stability of erythrocytes and liposomes and on the protein folding. Metronidazolum was shown to protectively act on the cell membranes. Besides the compound was able to decrease the folding rate of the protein catalase. The molecular mechanism of the compound effect on the cell membranes and proteins was supposed to be modification of the hydrogen bonds net of the surface water. The last was proved by the results of molecular dynamics computation of parameters of hydrogen bonds net and clusters of water molecules in metronidazolum solution and in the solutions of inactive compounds.

Paper Details

Date Published: 20 August 2004
PDF: 8 pages
Proc. SPIE 5474, Saratov Fall Meeting 2003: Optical Technologies in Biophysics and Medicine V, (20 August 2004); doi: 10.1117/12.579162
Show Author Affiliations
Era B. Popyhova, Saratov State Univ. (Russia)
Pavel E. Kuznetsov, Saratov State Univ. (Russia)
Svetlana M. Rogacheva, Saratov Military Institute of Radiological, Chemical and Biological Defense (Russia)
Konstantin I. Evlakov, Saratov State Univ. (Russia)
Sergey A. Tolmachev, Saratov State Univ. (Russia)
Machammad S. Kupadze, Saratov State Univ. (Russia)

Published in SPIE Proceedings Vol. 5474:
Saratov Fall Meeting 2003: Optical Technologies in Biophysics and Medicine V
Valery V. Tuchin, Editor(s)

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