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Proceedings Paper

Cluster model of protein molecule
Author(s): Andrey Yuri Chikishev; Yu. I. Kuargin; Yuri A. Romanovsky; E. G. Shidlovskaya
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Paper Abstract

The analysis of intradomain vibrations of the proteins in the 1011 -1O'3Hz range may be based on existence of domains or large clusters in the macromolecules connected by H-bonds and Van der Waals forces. As an example of such system we can consider the a-chymotrypsin 25 kD molecule with the two 12 kD subglobules. The active site of the enzyme molecule is located between the subglobules (Fig. la). The subglobular vibrations may lead to the lowering of the potential barrier for the proton transfer processes in the active site (Fig. 1 a,b)."2

Paper Details

Date Published: 1 May 1991
PDF: 5 pages
Proc. SPIE 1403, Laser Applications in Life Sciences, (1 May 1991); doi: 10.1117/12.57397
Show Author Affiliations
Andrey Yuri Chikishev, Moscow State Univ. (Russia)
Yu. I. Kuargin, Institute of Organic Chemistry (Russia)
Yuri A. Romanovsky, Moscow State Univ. (Russia)
E. G. Shidlovskaya, Moscow State Univ. (Russia)

Published in SPIE Proceedings Vol. 1403:
Laser Applications in Life Sciences
Sergei A. Akhmanov; Marina Yu. Poroshina, Editor(s)

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