Share Email Print

Proceedings Paper

Studies on the sonosensitization mechanism of ultrasound with ATX-70 in sonodynamic therapy
Author(s): Chunfeng Ding; Da Xing
Format Member Price Non-Member Price
PDF $17.00 $21.00

Paper Abstract

Sonodynamic therapy (SDT) is an effective method for cure tumors, but its mechanism is not clear up to now. In this work, the mechanism of SDT is analyzed by study the reaction between ultrasound and the gallium-porphyrin analogue ATX-70 experimentally. Results show that the ATX-70 is likely to play three roles in SDT. One is that the sonolumiescence (SL) react with ATX-70 directly, the action of ATX-70 is similarly to a sort of photosensitize. The other is that the high temperature produced in the bubbles at collapse makes ATX-70 into excitated states, the excitated ATX-70 react with the dissolved oxygen in liquid and produce oxygen free radicals. The third is that ATX-70 plays a role of surfactant in the process of cavitation and makes the cavitation become easily, lead to more high-energy hydroxide radicals are produced.

Paper Details

Date Published: 18 January 2005
PDF: 8 pages
Proc. SPIE 5630, Optics in Health Care and Biomedical Optics: Diagnostics and Treatment II, (18 January 2005); doi: 10.1117/12.572824
Show Author Affiliations
Chunfeng Ding, South China Normal Univ. (China)
Da Xing, South China Normal Univ. (China)

Published in SPIE Proceedings Vol. 5630:
Optics in Health Care and Biomedical Optics: Diagnostics and Treatment II
Britton Chance; Mingzhe Chen; Arthur E. T. Chiou; Qingming Luo, Editor(s)

© SPIE. Terms of Use
Back to Top
Sign in to read the full article
Create a free SPIE account to get access to
premium articles and original research
Forgot your username?