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Proceedings Paper

Expression of a proapoptotic Bcl-xl by low-energy laser irradiation in the amyloid beta 25-35 induced apoptosis of PC12 cells
Author(s): Lan Zhang; Xingyan Shen; Da Xing
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Paper Abstract

Among the many physiological effects of low-energy laser irradiation, anti-apoptosis functions have been reported. In our experiments A-beta was used to induce cells apoptosis and then the cells were dealt with low-energy laser irradiation (LELI), and finally the LELI effects to apoptosis were detected. The morphology of apoptotic cells was evaluated by fluorescence microscope. The molecular level of apoptosis was detected by quantifying the Bcl-xl mRNA expression using a new highly sensitive and quantitative polymerase chain reaction (QT-PCR) technique. The results show that the Bcl-xl mRNA expression went variety with different treatments to the cells. That indicates that the Bcl-xl is involved in the LELI effect of the Aβ-induced apoptosis.

Paper Details

Date Published: 18 January 2005
PDF: 9 pages
Proc. SPIE 5630, Optics in Health Care and Biomedical Optics: Diagnostics and Treatment II, (18 January 2005); doi: 10.1117/12.572797
Show Author Affiliations
Lan Zhang, South China Normal Univ. (China)
Xingyan Shen, South China Normal Univ. (China)
Da Xing, South China Normal Univ. (China)

Published in SPIE Proceedings Vol. 5630:
Optics in Health Care and Biomedical Optics: Diagnostics and Treatment II
Britton Chance; Mingzhe Chen; Arthur E. T. Chiou; Qingming Luo, Editor(s)

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