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Proceedings Paper

Glucose quantification in highly scattering media using diffuse reflectance polarization imaging
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Paper Abstract

Recently, polarization based optical approaches have received considerable interest due to their potential medical applications. Glucose, a chiral molecule, has the ability to rotate the plane of linearly polarized light, commonly referred to as optical activity, as well as affecting the refractive index of the media which is therefore affects the overall scattering coefficient in a given media. The magnitude of each effect is related to the concentration of glucose. Based on these effects, it would be expected that a change in glucose concentration would alter the diffuse reflectance polarization patterns from turbid media. In this study, we investigate how each of these effects is correlated to glucose concentration in a physiological range for highly scattering biological media. Furthermore, it is shown how diffusely polarized imaging when coupled with chemometrics techniques can be used to quantify glucose concentration.

Paper Details

Date Published: 7 December 2004
PDF: 5 pages
Proc. SPIE 5588, Smart Medical and Biomedical Sensor Technology II, (7 December 2004); doi: 10.1117/12.571444
Show Author Affiliations
Yanfang Li, Univ. of Toledo (United States)
Brent D. Cameron, Univ. of Toledo (United States)

Published in SPIE Proceedings Vol. 5588:
Smart Medical and Biomedical Sensor Technology II
Brian M. Cullum, Editor(s)

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