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Proceedings Paper

Optically and electrically addressed carbon nanofiber electrode arrays for intracellular interfacing
Author(s): Timothy E. McKnight; Anatoli V. Melechko; Guy D. Griffin; Seong-Ik Jun; Philip D. Rack; Michael A. Guillorn; Vladimir I. Merkulov; Michael L. Simpson
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Paper Abstract

Progress in the application of vertically-aligned carbon nanofibers (VACNF) as parallel subcellular and molecular-scale probes for biological manipulation and monitoring is reported. VACNFs possess many attributes that make them very attractive for implementation as functional, nanoscale features of microfabricated devices. For example, they can be synthesized at precise locations upon a substrate, can be grown many microns long, and feature sharp, nano-dimensioned tips. This, and their needlelike, vertical orientation upon a substrate, makes them particularly attractive as multielement cellular scale probes or as a parallel embodiment of traditional single-point microinjection or microelectrophysiological systems. We will overview our progress with fabricating and characterizing several embodiments of VACNF cell probing systems, which all feature arrays of nanoscale electrochemically-active probing regions at the tips of individually electrically-addressed nanofiber elements. We also overview our techniques of integrating these probing structures with intact cells and how these structures may be used on a massively parallel basis for measurement and control around and within viable cells.

Paper Details

Date Published: 7 December 2004
PDF: 8 pages
Proc. SPIE 5588, Smart Medical and Biomedical Sensor Technology II, (7 December 2004); doi: 10.1117/12.571375
Show Author Affiliations
Timothy E. McKnight, Oak Ridge National Lab. (United States)
Anatoli V. Melechko, Oak Ridge National Lab. (United States)
Univ. of Tennessee/Knoxville (United States)
Guy D. Griffin, Oak Ridge National Lab. (United States)
Seong-Ik Jun, Univ. of Tennessee/Knoxville (United States)
Philip D. Rack, Univ. of Tennessee/Knoxville (United States)
Michael A. Guillorn, Cornell Univ. (United States)
Vladimir I. Merkulov, Oak Ridge National Lab. (United States)
Michael L. Simpson, Oak Ridge National Lab. (United States)
Univ. of Tennessee/Knoxville (United States)

Published in SPIE Proceedings Vol. 5588:
Smart Medical and Biomedical Sensor Technology II
Brian M. Cullum, Editor(s)

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