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Proceedings Paper

Separation of blood cells and plasma in microchannel bend structures
Author(s): Christoph Blattert; Reinhold Jurischka; Andreas Schoth; Paul Kerth; Wolfgang Menz
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Paper Abstract

Biological applications of micro assay devices require easy implementable on-chip microfluidics for separation of plasma or serum from blood. This is achieved by a new blood separation technique based on a microchannel bend structure developed within the collaborative Micro-Tele-BioChip (μTBC) project. Different prototype polymer chips have been manufactured with an UV-LIGA process and hot embossing technology. The separation mechanisms have been identified and the separation efficiency of these chips has been determined by experimental measurements using human blood samples. Results show different separation efficiencies for cells and plasma up to 100 % depending on microchannel geometry, hematocrit, and feed velocity. This novel technique leads to an alternative blood separation method as compared to existing micro separation technologies.

Paper Details

Date Published: 8 December 2004
PDF: 9 pages
Proc. SPIE 5591, Lab-on-a-Chip: Platforms, Devices, and Applications, (8 December 2004); doi: 10.1117/12.568823
Show Author Affiliations
Christoph Blattert, Univ. Freiburg (Germany)
Reinhold Jurischka, Univ. Freiburg (Germany)
Andreas Schoth, Univ. Freiburg (Germany)
Paul Kerth, Preventor microTBC GmbH (Germany)
Wolfgang Menz, Univ. Freiburg (Germany)

Published in SPIE Proceedings Vol. 5591:
Lab-on-a-Chip: Platforms, Devices, and Applications
Linda A. Smith; Daniel Sobek, Editor(s)

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