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Proceedings Paper

Spray-jet assembly interface for the coupling of reversed-phase narrow-bore LC and FTIR spectrometry
Author(s): G. W. Somsen; Cees Gooijer; Udo A. T. Brinkman; Nel H. Velthorst; Tom Visser; A. P. J. M. de Jong
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Paper Abstract

Reversed phase liquid chromatography (RPLC) has been coupled to Fourier transform infrared spectrometry (FTIR) via solvent elimination and effluent deposition using a spray jet assembly. The chromatographic separation is hardly affected. Identification limits are in the 10 - 20 ng range. The system can handle eluent containing up to 40% water. The usefulness of the interface in impurity profiling of steroids is demonstrated.

Paper Details

Date Published: 1 March 1992
PDF: 2 pages
Proc. SPIE 1575, 8th Intl Conf on Fourier Transform Spectroscopy, (1 March 1992); doi: 10.1117/12.56475
Show Author Affiliations
G. W. Somsen, Free Univ. of Amsterdam (Netherlands)
Cees Gooijer, Free Univ. of Amsterdam (Netherlands)
Udo A. T. Brinkman, Free Univ. of Amsterdam (Netherlands)
Nel H. Velthorst, Free Univ. of Amsterdam (Netherlands)
Tom Visser, National Institute of Public Health and Environmental Protec (Netherlands)
A. P. J. M. de Jong, National Institute of Public Health and Environmental Protec (Netherlands)

Published in SPIE Proceedings Vol. 1575:
8th Intl Conf on Fourier Transform Spectroscopy
Herbert Michael Heise; Ernst Heiner Korte; Heinz W. Siesler, Editor(s)

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