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Proceedings Paper

The hyperspectral imaging endoscope: a new tool for in vivo cancer detection
Author(s): Erik H. Lindsley; Elliot S. Wachman; Daniel L. Farkas
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Paper Abstract

We developed a new endoscope that allows for non-contact, rapid (sub-second) acquisition of polarized spectral images of tissue in vivo. The intent was to enable exploration of a variety of optical contrast mechanisms (such as light absorption, reflectance, scattering, and fluorescence) in a search for new methods of early cancer detection in a clinical setting. Our first new implementation for cancer detection is based on a body of spectroscopic work that employs elastic scattering (Mie) theory to estimate the size of bulk scatterers in a given medium - in our case, the epithelial tissue of lungs. This paper describes the novel design of the Hyperspectral Imaging Endoscope, and our initial experiences with employing it for the early detection of dysplasia and cancer in lung epithelia.

Paper Details

Date Published: 1 July 2004
PDF: 8 pages
Proc. SPIE 5322, Imaging, Manipulation, and Analysis of Biomolecules, Cells, and Tissues II, (1 July 2004); doi: 10.1117/12.561884
Show Author Affiliations
Erik H. Lindsley, Carnegie Mellon Univ. (United States)
Univ. of Pittsburgh (United States)
Elliot S. Wachman, ChromoDynamics, Inc. (United States)
Daniel L. Farkas, Carnegie Mellon Univ. (United States)
Cedars-Sinai medical Ctr. (United States)

Published in SPIE Proceedings Vol. 5322:
Imaging, Manipulation, and Analysis of Biomolecules, Cells, and Tissues II
Dan V. Nicolau; Joerg Enderlein; Robert C. Leif; Daniel L. Farkas, Editor(s)

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