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Proceedings Paper

In vivo tomographic imaging based on bioluminescence
Author(s): Wenxiang Cong; Durairaj Kumar; Yubin Kang; Patrick Sinn; Earl Nixon; John Mienel Jr.; Melissa J. Suter; Lihong V. Wang; Geoffrey McLennan; Eric A. Hoffman; Ge Wang
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Paper Abstract

The most important task for bioluminescence imaging is to identify the emission source from the captured bioluminescent signal on the surface of a small tested animal. Quantitative information on the source location, geometry and intensity serves for in-vivo monitoring of infectious diseases, tumor growth, metastases in the small animal. In this paper, we present a point-spread function-based method for reconstructing the internal bioluminescent source from the surface light output flux signal. The method is evaluated for sensing the internal emission sources in nylon phantoms and within a live mouse. The surface bioluminescent signal is taken with a highly sensitive CCD camera. The results show the feasibility and efficiency of the proposed point-spread function-based method.

Paper Details

Date Published: 26 October 2004
PDF: 8 pages
Proc. SPIE 5535, Developments in X-Ray Tomography IV, (26 October 2004); doi: 10.1117/12.560522
Show Author Affiliations
Wenxiang Cong, Univ. of Iowa (United States)
Durairaj Kumar, Univ. of Iowa (United States)
Yubin Kang, Univ. of Iowa (United States)
Patrick Sinn, Univ. of Iowa (United States)
Earl Nixon, Univ. of Iowa (United States)
John Mienel Jr., Univ. of Iowa (United States)
Melissa J. Suter, Univ. of Iowa (United States)
Lihong V. Wang, Texas A&M Univ. (United States)
Geoffrey McLennan, Univ. of Iowa (United States)
Eric A. Hoffman, Univ. of Iowa (United States)
Ge Wang, Univ. of Iowa (United States)

Published in SPIE Proceedings Vol. 5535:
Developments in X-Ray Tomography IV
Ulrich Bonse, Editor(s)

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