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Proceedings Paper

Pathological calcifications studied with micro-CT
Author(s): Stuart R. Stock; Nalini M. Rajamannan; Ellen R. Brooks; Craig B. Langman; Lauren M. Pachman
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Paper Abstract

The microstructure of pathological biomineral deposits has received relatively little attention, perhaps, in part because of the difficulty preparing samples for microscopy. MicroCT avoids these difficulties, and laboratory microCT results are reviewed for aortic valve calcification (human as well as a rabbit model), for human renal calculi (stones) and for calcinoses formed in juvenile dermatomyositis (JDM). In calcified aortic valves of rabbits, numerical analysis of the data shows statistically significant correlation with diet. In a large kidney stone the pattern of mineralization is clearly revealed and may provide a temporal blueprint for stone growth. In JDM calcified deposits, very different microstructures are observed and may be related to processes unique to this disease.

Paper Details

Date Published: 26 October 2004
PDF: 8 pages
Proc. SPIE 5535, Developments in X-Ray Tomography IV, (26 October 2004); doi: 10.1117/12.560466
Show Author Affiliations
Stuart R. Stock, Northwestern Univ. (United States)
Nalini M. Rajamannan, Northwestern Univ. (United States)
Ellen R. Brooks, Northwestern Univ. (United States)
Craig B. Langman, Northwestern Univ. (United States)
Lauren M. Pachman, Northwestern Univ. (United States)

Published in SPIE Proceedings Vol. 5535:
Developments in X-Ray Tomography IV
Ulrich Bonse, Editor(s)

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