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Proceedings Paper

Refractive-index-sensitive, plasmon-resonant-scattering, and surface-enhanced Raman-scattering nanoparticles and arrays as biological sensing platforms
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Paper Abstract

The intense color of noble metal nanoparticles has inspired artists and fascinated scientists for hundreds of years. These rich hues are due to the interaction of light with the nanostructure's localized surface plasmon (LSPR). Here, we describe three optical sensing modalities that are dependant on the effects of the LSPR. Specifically, we will demonstrate the use of LSPR supporting particles as analogues to fluorescent probes and labels for multiplex detection, sensing based on observation of changes in the LSPR spectrum caused by alteration of the local refractive index upon analyte binding, and the spectroscopic labeling of cells and tissues with Surface Enhanced Raman Scatting (SERS) active nanoparticles probes.

Paper Details

Date Published: 16 June 2004
PDF: 14 pages
Proc. SPIE 5327, Plasmonics in Biology and Medicine, (16 June 2004); doi: 10.1117/12.554416
Show Author Affiliations
Douglas A. Stuart, Northwestern Univ. (United States)
Amanda J. Haes, Northwestern Univ. (United States)
Adam Dues McFarland, Northwestern Univ. (United States)
Shuming Nie, Emory Univ. (United States)
Georgia Technological Institute (United States)
Richard P. Van Duyne, Northwestern Univ. (United States)

Published in SPIE Proceedings Vol. 5327:
Plasmonics in Biology and Medicine
Tuan Vo-Dinh; Zygmunt Gryczynski; Joseph R. Lakowicz, Editor(s)

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