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Proceedings Paper

Dynamic characteristics of laser Doppler flowmetry signals obtained in response to a local and progressive pressure applied on diabetic and healthy subjects
Author(s): Anne Humeau; Audrey Koitka; Pierre Abraham; Jean-Louis Saumet; Jean-Pierre L'Huillier
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Paper Abstract

In the biomedical field, the laser Doppler flowmetry (LDF) technique is a non-invasive method to monitor skin perfusion. On the skin of healthy humans, LDF signals present a significant transient increase in response to a local and progressive pressure application. This vasodilatory reflex response may have important implications for cutaneous pathologies involved in various neurological diseases and in the pathophysiology of decubitus ulcers. The present work analyses the dynamic characteristics of these signals on young type 1 diabetic patients, and on healthy age-matched subjects. To obtain accurate dynamic characteristic values, a de-noising wavelet-based algorithm is first applied to LDF signals. All the de-noised signals are then normalised to the same value. The blood flow peak and the time to reach this peak are then calculated on each computed signal. The results show that a large vasodilation is present on signals of healthy subjects. The mean peak occurs at a pressure of 3.2 kPa approximately. However, a vasodilation of limited amplitude appears on type 1 diabetic patients. The maximum value is visualised, on the average, when the pressure is 1.1 kPa. The inability for diabetic patients to increase largely their cutaneous blood flow may bring explanations to foot ulcers.

Paper Details

Date Published: 1 September 2004
PDF: 8 pages
Proc. SPIE 5456, Photon Management, (1 September 2004); doi: 10.1117/12.544076
Show Author Affiliations
Anne Humeau, Ctr. Hospitalier/Univ. d'Angers (France)
Group ISAIP-ESAIP (France)
Audrey Koitka, Ctr. Hospitalier/Univ. d'Angers (France)
Group ISAIP-SAIP (France)
Pierre Abraham, Ctr. Hospitalier/Univ. d'Angers (France)
Group ISAIP-SAIP (France)
Jean-Louis Saumet, Ctr. Hospitalier/Univ. d'Angers (France)
Group ISAIP-SAIP (France)
Jean-Pierre L'Huillier, Ecole Nationale Superieure d'Arts et Metiers (France)

Published in SPIE Proceedings Vol. 5456:
Photon Management
Frank Wyrowski, Editor(s)

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