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Proceedings Paper

Image-guided laser thermal ablation therapy: a comparison of modeled tissue damage using interventional MR temperature images with tissue response
Author(s): Michael S. Breen; Kim Butts; Lili Chen; David L. Wilson
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Paper Abstract

Solid tumors and other pathologies can be treated using laser thermal ablation under interventional magnetic resonance imaging (iMRI) guidance. We developed a model to predict cell death from MR thermometry measurements and applied it to in vivo rabbit brain data. We aligned post-ablation MR lesion images to gradient echo images, from which temperature is derived, using a mutual information registration method. We used the outer boundary of the hyperintense rim in the post-ablation MR lesion image as the boundary for cell death, as verified from histology. Model parameters were simultaneously estimated using an iterative optimization algorithm applied to every interesting voxel in 185 images from multiple experiments having various temperature histories. The model gave a voxel sensitivity and specificity of 86.9% and 98.8%, respectively. Mislabeled voxels typically were within one voxel of the segmented necrotic boundary. This is good evidence that iMRI temperature maps can be used with our model to predict therapeutic regions in real-time.

Paper Details

Date Published: 5 May 2004
PDF: 8 pages
Proc. SPIE 5367, Medical Imaging 2004: Visualization, Image-Guided Procedures, and Display, (5 May 2004); doi: 10.1117/12.535942
Show Author Affiliations
Michael S. Breen, Case Western Reserve Univ. (United States)
Kim Butts, Stanford Univ. (United States)
Lili Chen, Fox Chase Cancer Ctr. (United States)
David L. Wilson, Case Western Reserve Univ. (United States)
Univ. Hospitals of Cleveland (United States)


Published in SPIE Proceedings Vol. 5367:
Medical Imaging 2004: Visualization, Image-Guided Procedures, and Display
Robert L. Galloway Jr., Editor(s)

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