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Proceedings Paper

Fluorescence demarcation of basal cell carcinoma controlled by histopathological mapping
Author(s): Marica B. Ericson; Charlotta Berndtsson; Bo Stenquist; Lena Molne; Olle Larko; Ann-Marie Wennberg; Arne Rosen
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Paper Abstract

The demand for fast and effective tools for diagnosis of skin cancer is increasing due to the escalating incidence of skin cancer in recent years. Fluorescence imaging has gained rising interest for detection and delineation of basal cell carcinoma (BCC), which is the most common type of skin cancer. By applying delta-5-aminolaevulinic acid (ALA) protoporphyrin IX (Pp IX) is accumulated in the tumour; hence, the Pp IX can be used as a fluorescent marker for tumours. More information may be obtained by combining the ALA induced fluorescence with fluorescence without externally applied fluorophore, so called autofluorescence. In this work we present a method for demarcation of BCC, using a non-expensive multispectral imaging set up assisted by image warping for image alignment. To calibrate the method, histopathological mapping has been carried out by excising the tumours with Mohs micrographic surgery. The Z-images, combining information of autofluorescence and ALA induced fluorescence, showed good agreement with the histopathological mapping of BCCs located on the face in 5 out of 12 patients and partial agreement in 7 patients. Since the face is an area where demarcation of tumours usually is considered difficult, this result shows a potential for the method as a pre-operative guiding tool for this type of skin lesions.

Paper Details

Date Published: 12 May 2004
PDF: 8 pages
Proc. SPIE 5370, Medical Imaging 2004: Image Processing, (12 May 2004); doi: 10.1117/12.534949
Show Author Affiliations
Marica B. Ericson, Chalmers Univ. of Technology, Goteborg Univ. (Sweden)
Charlotta Berndtsson, Chalmers Univ. of Technology, Goteborg Univ. (Sweden)
Bo Stenquist, Sahlgrenska Univ. Hospital, Goteborg Univ. (Sweden)
Lena Molne, Sahlgrenska Univ. Hospital, Goteborg Univ. (Sweden)
Olle Larko, Sahlgrenska Univ. Hospital, Goteborg Univ. (Sweden)
Ann-Marie Wennberg, Sahlgrenska Univ. Hospital, Goteborg Univ. (Sweden)
Arne Rosen, Chalmers Univ. of Technology, Goteborg Univ. (Sweden)

Published in SPIE Proceedings Vol. 5370:
Medical Imaging 2004: Image Processing
J. Michael Fitzpatrick; Milan Sonka, Editor(s)

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