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Proceedings Paper

New results in computer-aided diagnosis (CAD) of breast cancer using a recently developed SVM/GRNN Oracle hybrid
Author(s): Walker H. Land Jr.; Lut Wong; Daniel W. McKee; Timothy Masters; Frances R. Anderson; Anurag Raturi; Joseph Y. Lo
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Paper Abstract

Breast cancer is second only to lung cancer as a tumor-related cause of death in women. Currently, the method of choice for the early detection of breast cancer is mammography. While sensitive to the detection of non palpable breast lesions, its positive predictive value (PPV) is low, resulting in biopsies that are only 15%-34% likely to reveal malignancy. This paper explores the use of a recently designed Support Vector Machine (SVM)/Generalized Regression Neural Network (GRNN) Oracle hybrid to classify breast lesions and evaluate the software's performance as an interpretive aid to radiologists. The main objective of the research was to perform an independent analysis, using a new, integrated film screen mammogram data base of approximately 2500 cases from five separate institutions, to verify results obtained previously[14]. This study demonstrated the following: (1) The DE crossover constant has little, if any, effect on measures of performance (MOP). (2) A specificity of approximately 5.6% is achieved at 100% sensitivity, which increases to approximately 36% at 95% sensitivity. (3) PPV increases from 51% to 56% as sensitivity is decreased from 100 to 95%, respectively.

Paper Details

Date Published: 12 May 2004
PDF: 8 pages
Proc. SPIE 5370, Medical Imaging 2004: Image Processing, (12 May 2004); doi: 10.1117/12.533142
Show Author Affiliations
Walker H. Land Jr., Binghamton Univ. (United States)
Lut Wong, Binghamton Univ. (United States)
Daniel W. McKee, Binghamton Univ. (United States)
Timothy Masters, TMAIC (United States)
Frances R. Anderson, Lourdes Hospital and Regional Cancer Ctr. (United States)
Anurag Raturi, Binghamton Univ. (United States)
Joseph Y. Lo, Duke Univ. Medical Ctr. (United States)

Published in SPIE Proceedings Vol. 5370:
Medical Imaging 2004: Image Processing
J. Michael Fitzpatrick; Milan Sonka, Editor(s)

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