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Proceedings Paper

Laser-induced photoacoustic tomography enhanced with an optical contrast agent
Author(s): Xueding Wang; Geng Ku; Xueyi Xie; Malgorzata A. Wegiel; Darryl J. Bornhop; George Stoica; Lihong V. Wang
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Paper Abstract

Optical contrast agents, such as indocyanine dyes, nano-particles and their functional derivatives, have been widely applied to enhance the sensitivity and specificity of optical imaging. However, due to the overwhelming scattering of light in biological tissues, the spatial resolution of traditional optical imaging degrades drastically as the imaging depth increases. For the first time to our knowledge, non-invasive in vivo photoacoustic imaging of an optical contrast agent, distributed in the rat brain, was implemented with near-infrared light. Injection of indocyanine green polyethylene glycol, a contrast agent with a high absorption at the 805-nm wavelength, into the circulatory system of a rat enhanced the absorption contrast between the blood vessels and the background brain tissues. Because near-infrared light can penetrate deep into the brain tissues through the skin and skull, we were able to successfully reconstruct the vascular distribution in the rat brain from the detected photoacoustic signals. The dynamic concentration of this contrast agent in the brain blood after the intravenous injection was also studied. This work proved that the distribution of an exogenous contrast agent in biological tissues can be imaged clearly and accurately by photoacoustic tomography. This new technology has high potential for application in dynamic and molecular medical imaging.

Paper Details

Date Published: 12 July 2004
PDF: 6 pages
Proc. SPIE 5320, Photons Plus Ultrasound: Imaging and Sensing, (12 July 2004); doi: 10.1117/12.532434
Show Author Affiliations
Xueding Wang, Texas A&M Univ. (United States)
Geng Ku, Texas A&M Univ. (United States)
Xueyi Xie, Texas A&M Univ. (United States)
Malgorzata A. Wegiel, Texas Tech Univ. (United States)
Darryl J. Bornhop, Vanderbilt Univ. (United States)
George Stoica, Texas A&M Univ. (United States)
Lihong V. Wang, Texas A&M Univ. (United States)

Published in SPIE Proceedings Vol. 5320:
Photons Plus Ultrasound: Imaging and Sensing
Alexander A. Oraevsky; Lihong V. Wang, Editor(s)

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