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Proceedings Paper

Kerr-gated picosecond Raman spectroscopy and Raman photon migration of equine bone tissue with 400-nm excitation
Author(s): Michael D. Morris; Allen E. Goodship; Edward R. C. Draper; Pavel Matousek; Michael Towrie; Anthony W. Parker
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Paper Abstract

We show that Raman spectroscopy with visible lasers, even in the deep blue is possible with time-gated Raman spectroscopy. A 4 picosec time gate allows efficient fluorescence rejection, up to 1000X, and provides almost background-free Raman spectra with low incident laser power. The technology enables spectroscopy with better than 10X higher scattering efficiency than is possible with the NIR (785 nm and 830 nm) lasers that are conventionally used. Raman photon migration is shown to allow depth penetration. We show for the first time that Kerr-gated Raman spectra of bone tissue with blue laser excitation enables both fluorescence rejection and depth penetration.

Paper Details

Date Published: 1 July 2004
PDF: 6 pages
Proc. SPIE 5321, Biomedical Vibrational Spectroscopy and Biohazard Detection Technologies, (1 July 2004); doi: 10.1117/12.531517
Show Author Affiliations
Michael D. Morris, Univ. of Michigan (United States)
Allen E. Goodship, Royal Veterinary College (United Kingdom)
Edward R. C. Draper, Royal Veterinary College (United Kingdom)
Pavel Matousek, Rutherford Appleton Lab. (United Kingdom)
Michael Towrie, Rutherford Appleton Lab. (United Kingdom)
Anthony W. Parker, Rutherford Appleton Lab. (United Kingdom)

Published in SPIE Proceedings Vol. 5321:
Biomedical Vibrational Spectroscopy and Biohazard Detection Technologies
Zygmunt Gryczynski; Anita Mahadevan-Jansen; Michael G. Sowa; Tuan Vo-Dinh; Joseph R. Lakowicz; Gerwin J. Puppels, Editor(s)

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