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Proceedings Paper

Real-time measurement of in-vitro and in-vivo blood flow with Fourier domain optical coherence tomography
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Paper Abstract

We realized an in vivo Fourier domain optical coherence tomography (FD OCT) setup that allows acquiring retinal depth scans at a rate of 25.000 per second. We demonstrate the possibility to measure Doppler flow depth profile in specific regions of interest. The method to extract the flow profiles is based on a local phase analysis of the backscattered signal and allows for bidirectional Doppler flow imaging. The velocity resolution in tissue is 200μm/s. We verified the method by measuring pump controlled in vitro flow through a glass capillary. The system allows for a real-time colour encoded Doppler tomogram rate of 2-4 per second. We recorded the pulsatility of different vessels close to optic nerve head.

Paper Details

Date Published: 1 July 2004
PDF: 6 pages
Proc. SPIE 5316, Coherence Domain Optical Methods and Optical Coherence Tomography in Biomedicine VIII, (1 July 2004); doi: 10.1117/12.531327
Show Author Affiliations
Rainer Leitgeb, Univ. of Vienna (Austria)
Leopold Schmetterer, Univ. of Vienna (Austria)
Wolfgang Drexler, Univ. of Vienna (Austria)
Fatmire Berisha, Vienna General Hospital (Austria)
Christoph K. Hitzenberger, Univ. of Vienna (Austria)
Maciej Wojtkowski, Nicolaus Copernicus Univ. (Poland)
Tomasz Bajraszewski, Nicolaus Copernicus Univ. (Poland)
Adolf F. Fercher, Univ. of Vienna (Austria)

Published in SPIE Proceedings Vol. 5316:
Coherence Domain Optical Methods and Optical Coherence Tomography in Biomedicine VIII
Valery V. Tuchin; Joseph A. Izatt; James G. Fujimoto, Editor(s)

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