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Proceedings Paper

Noninvasive evaluation of mini-invasive femtosecond laser refractive surgery
Author(s): Meng Han; Leander Zickler; Matthias Walter; Guenter Giese; Frieder Loesel; Josef F. Bille
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Paper Abstract

Nd:glass femtosecond laser is promising as next generation mini-invasive eye surgical laser, with the advantages of excellent beam quality, high surgical precision and minimized side effects. However, there are still many open questions concerning the precision, efficiency and collateral effects of femtosecond laser refractive surgery. By non-invasive microscopic imaging methods including confocal, multiphoton, second harmonic and atomic force microscopy, we successfully characterized the three dimensional corneal ultrastructure without applying fixation and slicing. Based on the intrinsic properties of collagen, second harmonic cornea imaging proved to be outstanding to analyze the outcome of femtosecond laser intrastromal ablations. Strong contrast and large sensing depth second harmonic image was obtained without fixation, sectioning or labelling. The three dimensional ultrastructure of porcine cornea after Nd:glass femtosecond laser intrastromal surgery was examined to evaluate the concepts of minimum-invasive all-optical refractive eye surgery. No thermal damages were recognized and the surgical outcome appeared highly predictable. Due to the similarities between the physical principals of nonlinear laser scanning microscopy and femtosecond laser ablations, a setup of the Nd:glass femtosecond laser system integrating both the surgery and probing functions was proposed.

Paper Details

Date Published: 1 June 2004
PDF: 11 pages
Proc. SPIE 5340, Commercial and Biomedical Applications of Ultrafast Lasers IV, (1 June 2004); doi: 10.1117/12.530524
Show Author Affiliations
Meng Han, Ruprecht-Karls-Univ. Heidelberg (Germany)
Leander Zickler, Ruprecht-Karls-Univ. Heidelberg (Germany)
Matthias Walter, Ruprecht-Karls-Univ. Heidelberg (Germany)
Guenter Giese, Max-Planck-Institut fur Medizinische Forschung (Germany)
Frieder Loesel, 20/10 Perfect Vision GmbH (Germany)
Josef F. Bille, Ruprecht-Karls-Univ. Heidelberg (Germany)

Published in SPIE Proceedings Vol. 5340:
Commercial and Biomedical Applications of Ultrafast Lasers IV
Joseph Neev; Christopher B. Schaffer; Andreas Ostendorf, Editor(s)

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