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Proceedings Paper

In vivo optical coherence tomography in endoscopic diagnostics of bladder disease
Author(s): Dmitri Daniltchenko; Eva Lankenau; Frank Konig; Brian Shay; Gereon Huettmann; Markus D. Sachs; Dietmar Schnorr; Stefan A. Loening
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Paper Abstract

Purpose: OCT is a new imaging method which produces a 3 mm wide x 2.5 mm deep 2D picture with a resolution of 15 μm. Materials and Methods: We utilised the Tomograph Sirius 713, developed at the Medical Laser Centre in cooperation with 4-Optics AG, Lubeck, Germany. This apparatus uses a special Super-Luminescence-Diode (SLD) that produces light within the near infrared wavelength, with a central wavelength of 1300 nm and spectral width of 45 nm. The coherence length is reduced to 15 μm. The light is introduced into a fibreglass optic which is a couple of meters long and is easy to handle. To measure the depth of invasion and position of urothelial bladder tumours, the fibreglass optic is attached to a regular endoscope (Wolf, Knittlingen, Germany) via a OCT adapter. That way, in parallel to the regular endoscopic view of the bladder mucosa with or without pathologic findings, an OCT picture of the superficial as well as the deeper muscle layers is visible online. OCT was used to obtaine 275 images from the bladder of 30 patients. Results: OCT of normal bladder mucosa produces an image with a cross section of up to 2.5 mm. It is possible to distinguish transitional epithelium, lamina propria, smooth muscles and capillaries. In cystitis the thickness of the mucosa is constant, but the distinction between the different layers is blurred. In squamous metaplasia there is thickening of the epithelial layer, with preservation of lamination of the lower layers. In transitional cell carcinoma there is a complete loss of the regular layered structure. Thus, the border between tumour and normal bladder tissue can be easily distinguished. Conclusions: This method can provide valuable information on tumour invasion and extension in real time and therefore influence therapeutic strategies

Paper Details

Date Published: 1 July 2004
PDF: 6 pages
Proc. SPIE 5316, Coherence Domain Optical Methods and Optical Coherence Tomography in Biomedicine VIII, (1 July 2004); doi: 10.1117/12.530207
Show Author Affiliations
Dmitri Daniltchenko, Klinik fur Urologie der Charite, Humboldt-Univ. zu Berlin (Germany)
Eva Lankenau, Medizinisches Laserzentrum Lubeck (Germany)
Frank Konig, Klinik fur Urologie der Charite, Humboldt-Univ. zu Berlin (Germany)
Brian Shay, Klinik fur Urologie der Charite, Humboldt-Univ. zu Berlin (Germany)
Gereon Huettmann, Medizinisches Laserzentrum Lubeck (Germany)
Markus D. Sachs, Klinik fur Urologie der Charite, Humboldt-Univ. zu Berlin (Germany)
Dietmar Schnorr, Klinik fur Urologie der Charite, Humboldt-Univ. zu Berlin (Germany)
Stefan A. Loening, Klinik fur Urologie der Charite, Humboldt-Univ. zu Berlin (Germany)


Published in SPIE Proceedings Vol. 5316:
Coherence Domain Optical Methods and Optical Coherence Tomography in Biomedicine VIII
Valery V. Tuchin; Joseph A. Izatt; James G. Fujimoto, Editor(s)

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