We have recently developed a new approach to glucose sensing based on the aggregation of nanometer-sized noble-metal nanoparticles and their respective change in plasmon absorption upon glucose addition. High molecular weight Dextran coated nanoparticles are aggregated with Concanavalin A, (Con A), where the aggregation results in a significant shift in metal-plasmon absorption. The addition of glucose competitively binds to Con A, reducing nanoparticle aggregation, and therefore the plasmon absorption when monitored at 650 nm. We have optimized our plasmonic glucose sensing mechanism with regard to nanoparticle stability, the dynamic range for glucose sensing and the wavelength of observation, to be compatible with both clinical glucose requirements and measurements.

Date Published: 16 June 2004
PDF: 9 pages
Proc. SPIE 5327, Plasmonics in Biology and Medicine, (16 June 2004); doi: 10.1117/12.530156

Published in SPIE Proceedings Vol. 5327:
Plasmonics in Biology and Medicine
Tuan Vo-Dinh; Zygmunt Gryczynski; Joseph R. Lakowicz, Editor(s)