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Proceedings Paper

Role of Toll-like receptors in photodynamic-therapy-elicited host response
Author(s): Mladen Korbelik
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Paper Abstract

Treatment of solid tumors by photodynamic therapy (PDT) induces a host reaction, coordinated through a network of inflammatory and immune responses, that plays an important role in the therapy outcome. It is suggested that this host response is initiated by altered self-associated endogenous danger signals massively released from PDT-treated tumors. Toll-like receptors, localized predominantly in the membrane of immune cells, are the major sensors of the recognition arm of the innate immune system. The engagement of these receptors by PDT-generated danger signals prompts the activation of the networks of innate immunity signaling pathways leading to the downstream activation of nuclear transcription factors responsible for the transcription of inflammatory/immune response-associated genes. The contribution of PDT-induced host response to the therapeutic outcome depends on the balance between the tissue-destructive action of inflammatory/immune effectors and the impact of concomitantly mobilized negative regulatory mechanisms evolved for controlling the intensity and duration of inflammatory and immune responses.

Paper Details

Date Published: 1 July 2004
PDF: 9 pages
Proc. SPIE 5319, Laser Interaction with Tissue and Cells XV, (1 July 2004);
Show Author Affiliations
Mladen Korbelik, British Columbia Cancer Agency (Canada)

Published in SPIE Proceedings Vol. 5319:
Laser Interaction with Tissue and Cells XV
Steven L. Jacques; William P. Roach, Editor(s)

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