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Proceedings Paper

Evaluation of photothermal tomography for imaging the microvasculature of human skin
Author(s): Bernard Choi; Boris Majaron; John Stuart Nelson M.D.
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Paper Abstract

Photothermal tomography (PTT) can provide volumetric images of chromophore heating. To evaluate the accuracy of PTT for blood vessel imaging, we used a computational model to simulate an object vessel at various depths and calculate resultant infrared emission frame sequences after pulsed laser excitation. We then applied an inversion algorithm to obtain three-dimensional PTT images, which were then compared with the respective modeled objects. We found that PTT can determine accurately vessel depth, but lateral and longitudinal spatial resolution degrade considerably with increasing depth. To improve the performance of PTT, we propose a simple technique to estimate the actual vessel diameter using an empirically determined, depth resolved linespread function.

Paper Details

Date Published: 1 July 2004
PDF: 5 pages
Proc. SPIE 5318, Advanced Biomedical and Clinical Diagnostic Systems II, (1 July 2004); doi: 10.1117/12.529318
Show Author Affiliations
Bernard Choi, Univ. of California/Irvine (United States)
Boris Majaron, Institute Jozef Stefan (Slovenia)
Univ. of California/Irvine (United States)
John Stuart Nelson M.D., Univ. of California/Irvine (United States)

Published in SPIE Proceedings Vol. 5318:
Advanced Biomedical and Clinical Diagnostic Systems II
Gerald E. Cohn; Warren S. Grundfest M.D.; David A. Benaron M.D.; Tuan Vo-Dinh, Editor(s)

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