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Proceedings Paper

Physical basis of holographic optical coherence imaging of living tissue
Author(s): David D. Nolte; Kwan Jeong; Ping Yu; John J. Turek
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Paper Abstract

This paper reviews the physical basis of holographic optical coherence imaging (OCI) applied in image-domain holography (IDH) and Fourier-domain holography (FDH). Holographic OCI is a multi-spatial-channel direct imaging approach that is closely related to short-coherence speckle interferometry and speckle holography, drawing in addition from laser-ranging concepts and techniques of optical coherence tomography (OCT). It produces a series of en face images at successive depths that can be presented in a so-called video "fly-through". Interchannel cross-talk is described as multichannel spatial heterodyne that produces image-bearing speckle. The speckle holograms are proposed to relate to specific structure in the tissue and may be useful as a clinical diagnostic. For instance, sub-cellular motility (a metric of the vitality of a cell and a means to quantify the response to inter-cellular signaling) can be detected with wide field of view without the need for cellular-scale optical resolution. This can be applied across biologically significant areas of tissue with potential for intraoperative applications to asses the state of health beneath the surface of broad areas of excised tissue.

Paper Details

Date Published: 1 July 2004
PDF: 7 pages
Proc. SPIE 5316, Coherence Domain Optical Methods and Optical Coherence Tomography in Biomedicine VIII, (1 July 2004); doi: 10.1117/12.529299
Show Author Affiliations
David D. Nolte, Purdue Univ. (United States)
Kwan Jeong, Purdue Univ. (United States)
Ping Yu, Univ. of Missouri/Columbia (United States)
John J. Turek, Purdue Univ. (United States)

Published in SPIE Proceedings Vol. 5316:
Coherence Domain Optical Methods and Optical Coherence Tomography in Biomedicine VIII
Valery V. Tuchin; Joseph A. Izatt; James G. Fujimoto, Editor(s)

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