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Proceedings Paper

Quantification of photoreceptor layer thickness in different macular pathologies using ultrahigh-resolution optical coherence tomography
Author(s): Wolfgang Drexler; Boris Hermann; Angelika Unterhuber; Harald Sattmann; Matthias Wirtitsch; Michael Stur; Christoph Scholda; Erdem Ergun; Elisabeth Anger; Tony H. Ko; Christian Schubert; Peter K. Ahnelt; James G. Fujimoto; Adolf F. Fercher
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Paper Abstract

In vivo ultrahigh resolution ophthalmic OCT has been performed in more than 300 eyes of 200 patients with several retinal pathologies, demonstrating unprecedented visualization of all major intraretinal layers, in particular the photoreceptor layer. Visualization as well as quantification of the inner and outer segment of the photoreceptor layer especially in the foveal region has been acvhieved. In normal subjects the photoreceptor layer thickness in the center of the fovea is about of 90 μm, approximately equally distributed to the inner and the outer photoreceptor segment. In the parafoveal region this thickness is reduced to ~50 μm (~30 μm for the inner and ~20 μm for the outer segment). This is in good agreement with well known increase of cone outer segments in the central foveal region. Photoreceptor layer impairment in different macular pathologies like macular hole, central serous chorioretinopathy, age related macular degeneration, foveomacular dystrophies, Stargardt dystrophy as well as retinitis pigmentosa has been investigated. Photoreceptor layer loss significantly correlated with visual acuity (R2 = 0.6, p < 0.001) and microperimetry findings for the first time in 22 eyes with Stargardt dystrophy. Visualization and quantification of photoreceptor inner and outer segment using ultrahigh resolution OCT has the potential to improve early ophthalmic diagnosis, contributes to a better understanding of pathogenesis of retinal diseases as well as might have impact in the development and monitoring of novel therapy approaches.

Paper Details

Date Published: 13 July 2004
PDF: 6 pages
Proc. SPIE 5314, Ophthalmic Technologies XIV, (13 July 2004); doi: 10.1117/12.528646
Show Author Affiliations
Wolfgang Drexler, Univ. of Vienna (Austria)
Boris Hermann, Univ. of Vienna (Austria)
Angelika Unterhuber, Univ. of Vienna (Austria)
Harald Sattmann, Univ. of Vienna (Austria)
Matthias Wirtitsch, General Hospital of Vienna (Austria)
Michael Stur, General Hospital of Vienna (Austria)
Christoph Scholda, General Hospital of Vienna (Austria)
Erdem Ergun, General Hospital of Vienna (Austria)
Elisabeth Anger, Univ. of Vienna (Austria)
Tony H. Ko, Massachusetts Institute of Technology (United States)
Christian Schubert, Univ. of Vienna (Austria)
Peter K. Ahnelt, Univ. of Vienna (Austria)
James G. Fujimoto, Massachusetts Institute of Technology (United States)
Adolf F. Fercher, Univ. of Vienna (Austria)

Published in SPIE Proceedings Vol. 5314:
Ophthalmic Technologies XIV
Fabrice Manns; Per G. Soderberg; Arthur Ho, Editor(s)

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