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Proceedings Paper

Noncoherent light for PDT of spontaneous animal tumors
Author(s): Michael D. Lucroy; Tisha D. Ridgway; Russell G. Higbee; Kimberly Reeds
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Paper Abstract

Cultured 9L cells were incubated with graded doses of pheophorbide-a-hexyl ether (HPPH) and exposed to 665 nm red light from either a noncoherent light source or a KTP-pumped dye laser. Cell death was observed after irradiation using either light source, with the noncoherent light being most effective at the highest HPPH concentrations. To determing the practicality of using the noncoherent light source for clinical PDT, dogs and cats with spontaneous tumors were injected intravenously with 0.15 mg/kg HPPH one hour before their tumors were irradiated with 665 nm noncoherent light (50 mW cm-2, 100 J cm-2). Of the 9 tumors treated, 8 complete responses were observed, all of which occurred in animals with squamous cell carcinoma. After 68 weeks of follow up, the median initial disease free interval had not been reached. These data support the use of noncoherent light sources for PDT of spontaneous tumors in animals, representing a cost-effective alternative to medical lasers in both veterinary and human dermatology and oncology.

Paper Details

Date Published: 13 July 2004
PDF: 4 pages
Proc. SPIE 5312, Lasers in Surgery: Advanced Characterization, Therapeutics, and Systems XIV, (13 July 2004); doi: 10.1117/12.527446
Show Author Affiliations
Michael D. Lucroy, Purdue Univ. (United States)
Tisha D. Ridgway, Univ. of Oklahoma Health Sciences Ctr. (United States)
Russell G. Higbee, Sciperio Inc. (United States)
Kimberly Reeds, Oklahoma State Univ. (United States)

Published in SPIE Proceedings Vol. 5312:
Lasers in Surgery: Advanced Characterization, Therapeutics, and Systems XIV
Brian Jet-Fei Wong M.D.; Nikiforos Kollias; Kenton W. Gregory M.D.; Henry Hirschberg; Reza S. Malek M.D.; Abraham Katzir; David S. Robinson M.D.; Kenneth Eugene Bartels D.V.M.; Eugene A. Trowers M.D.; Werner T.W. de Riese; Lawrence S. Bass M.D.; Lloyd P. Tate V.D.M.; Steen J. Madsen; Keith D. Paulsen; Karen M. McNally-Heintzelman, Editor(s)

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