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Proceedings Paper

Interstitial light application for photodynamic therapy in a rat brain tumor model
Author(s): Even Angell-Petersen; Dag R. Sorensen V.D.M.; Steen J. Madsen; Henry Hirschberg M.D.
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Paper Abstract

The usefulness of repetitive ALA mediated PDT is being evaluated in a rat brain tumor model. In preliminary experiments an optical fiber was repeatedly introduced directly into the brain to apply light, requiring multiple surgical procedures. In an attempt to refine the animal model, an indwelling light applicator, using a modified microdialysis guide cannula has been developed. The cannula is fixed to the scull and can remain in the rat brain for several weeks without complications. In studies of repetitive PDT the need for repeated mounting in a stereotactic frame and surgical procedures can be eliminated. The applicator also makes it feasible to employ low fluence rates with long treatment times, which correspond to future clinically relevant protocols. The fluence rate distribution was measured in vivo and compared to diffusion theory and Monte Carlo simulations to estimate the tissue optical properties of the rat brain for light at 632 nm. The modeling suggested a reduced scattering coefficient 38 cm-1, an absorption coefficient 0.46 cm-1 and a penetration depth 0.14 cm.

Paper Details

Date Published: 13 July 2004
PDF: 9 pages
Proc. SPIE 5312, Lasers in Surgery: Advanced Characterization, Therapeutics, and Systems XIV, (13 July 2004); doi: 10.1117/12.527417
Show Author Affiliations
Even Angell-Petersen, Norwegian Radium Hospital (Norway)
Dag R. Sorensen V.D.M., Rikshospitalet Universitetsklinikk (Norway)
Steen J. Madsen, Univ. of Nevada/Las Vegas (United States)
Henry Hirschberg M.D., Rikshospitalet Universitetsklinikk (Norway)

Published in SPIE Proceedings Vol. 5312:
Lasers in Surgery: Advanced Characterization, Therapeutics, and Systems XIV
Brian Jet-Fei Wong M.D.; Nikiforos Kollias; Kenton W. Gregory M.D.; Henry Hirschberg; Reza S. Malek M.D.; Abraham Katzir; David S. Robinson M.D.; Kenneth Eugene Bartels D.V.M.; Eugene A. Trowers M.D.; Werner T.W. de Riese; Lawrence S. Bass M.D.; Lloyd P. Tate V.D.M.; Steen J. Madsen; Keith D. Paulsen; Karen M. McNally-Heintzelman, Editor(s)

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