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Proceedings Paper

CMOS focal-plane-array for analysis of enzymatic reaction in system-on-chip spectrophotometer
Author(s): Dong Wang; Chanki Ha; Chan Beum Park; Youngjoong Joo
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Paper Abstract

A CMOS focal-plane-array is designed for the high-throughput analysis of enzymatic reaction in on-chip spectrophotometer system. One of potential applications of the presented prototype system is to perform enzymatic analysis of biocompounds contained in blood. This function normally requires an expensive diode-array spectrophotometer, but it is possible to perform high throughput analysis with low budget if the spectrophotometer system is scaled down to a chip. The CMOS active pixel sensor array can cover a layer of polydimethylsiloxane (PDMS) forming the microfluidic channels and the substrate solution for enzymatic reaction can be injected into the channels by capillary force. Under room light, the underneath CMOS active pixel sensor with 40 x 40 pixels detect the gray levels of the fluid’s color. Inside the image sensor chip (size: 3mm x 3mm), the pixels of the same column share the same sample and hold circuits. The analog signals from 40 columns are multiplexed into one input feeding an on-chip 8 bits dual-slope analog to digital converter. The color change can be displayed on the external monitor by using a data acquisition card and personal computer.

Paper Details

Date Published: 7 June 2004
PDF: 9 pages
Proc. SPIE 5301, Sensors and Camera Systems for Scientific, Industrial, and Digital Photography Applications V, (7 June 2004); doi: 10.1117/12.526364
Show Author Affiliations
Dong Wang, Arizona State Univ. (United States)
Chanki Ha, Arizona State Univ. (United States)
Chan Beum Park, Arizona State Univ. (United States)
Youngjoong Joo, Arizona State Univ. (United States)

Published in SPIE Proceedings Vol. 5301:
Sensors and Camera Systems for Scientific, Industrial, and Digital Photography Applications V
Nitin Sampat; Morley M. Blouke; Ricardo J. Motta, Editor(s)

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