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Proceedings Paper

Two-photon absorption-induced drug delivery from polymers for medical applications
Author(s): Hee-Cheol Kim; Stefan Kreiling; Sebastian Haertner; Lutz Hesse; Andreas Greiner; Norbert A. Hampp
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Paper Abstract

Novel polymeric materials carrying a drug depot have been developed which are suitable for fabrication of photochemically modulated drug delivery devices. In order to avoid uncontrolled drug release the drug is covalently attached to the polymer backbone using a photo-active linker. Controlled drug release from the polymer can be accomplished either via single-photon excitation or by two-photon absorption (TPA). In particular the second possibility is of interest for applications where exposure to day light or UV light may not be omitted. One example are polymeric intraocular lenses (IOL), which are implanted instead of the opaque natural lens during cataract surgery. Secondary cataract formation is quite often observed after implantation of polymeric IOLs. In this study the well known cell toxic agent 5-fluorouracil (5FU) attached to a methylmethacrylate-based polymer was investigated as an IOL which can upon photochemical excitation release 5FU in order to treat or to prevent secondary cataract formation. The photochemical cleavage of the linker molecule was analyzed with single- and two-photon excitation. UV/VIS spectroscopy and HPLC analysis confirmed the release of 5FU form the polymer backbone. The diffusion of the drug precursor out from the polymer as well as the hydrolysis of the drug precursor which leads to 5FU formation were investigated in vitro.

Paper Details

Date Published: 21 June 2004
PDF: 8 pages
Proc. SPIE 5323, Multiphoton Microscopy in the Biomedical Sciences IV, (21 June 2004); doi: 10.1117/12.523588
Show Author Affiliations
Hee-Cheol Kim, Univ. Marburg (Germany)
Stefan Kreiling, Univ. Marburg (Germany)
Sebastian Haertner, Univ. Marburg (Germany)
Lutz Hesse, Klinikum Heilbronn (Germany)
Andreas Greiner, Univ. Marburg (Germany)
Norbert A. Hampp, Univ. Marburg (Germany)

Published in SPIE Proceedings Vol. 5323:
Multiphoton Microscopy in the Biomedical Sciences IV
Ammasi Periasamy; Peter T. C. So, Editor(s)

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