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Proceedings Paper

Computer simulation of pressure-wave generation in biological media by pulsed lasers with various beam profiles
Author(s): Steven L. Jacques
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Paper Abstract

Pressure waves can be generated in biological tissues by pulsed lasers which deposit optical energy in absorbing structures such as blood vessels. Arrays of acoustic detectors on a tissue surface can sense the arrival of such waves. Analysis of the time-resolved signals can be used to reconstruct the 3-D distribution of the absorbing structures. In this report, a computer simulation was developed (see code listed in Appendix) to predict the time-resolved spatial distribution of pressure in a tissue in response to a pulse laser beam. In particular, the temporal history of pressure generated in a sphere of uniform energy deposition was calculated to illustrate the calibration of the computation. The temporal histories of pressures generated by a flat-field beam and a Gaussian-profile beam are also presented. The results show that the sharp edge of the flat-field beam yields tensile pressure wave and the pressure pattern is significantly different than the pressures produced by the smoother Gaussia-profile beam. The computer simulation is a very simple computation that is a valuable tool for predicting expected experimental results, and may be used in a reconstruction algorithm. This paper can be viewed at

Paper Details

Date Published: 13 October 2003
PDF: 12 pages
Proc. SPIE 5068, Saratov Fall Meeting 2002: Optical Technologies in Biophysics and Medicine IV, (13 October 2003); doi: 10.1117/12.518748
Show Author Affiliations
Steven L. Jacques, Oregon Medical Laser Ctr. (United States)
Oregon Health and Science Univ. (United States)

Published in SPIE Proceedings Vol. 5068:
Saratov Fall Meeting 2002: Optical Technologies in Biophysics and Medicine IV
Valery V. Tuchin, Editor(s)

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