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Proceedings Paper

Cellular mechanisms of low-power laser therapy
Author(s): Tiina I. Karu
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Paper Abstract

Cytochrome c oxidase is considered as the photoacceptor when eukaryotic cells are exposed to monochromatic red to near-IR radiation. Five primary mechanisms are discussed: changes in the redox properties of the respiratory chain components following photoexcitation of their electronic states, NO release from catalytic center of cytochrome c oxidase, generation of singlet oxygen, localized transient heating of absorbing chromophores, in creased superoxide anion production with a subsequent increase in the concentration of H2O2. A cascade of reactions related to the alteration of cellular homeostasis parameters (pHi, [Cai], cAMP, Eh, [ATP] and some others) is considered as a photosignal transduction and amplification chain in a cell (secondary mechanisms).

Paper Details

Date Published: 22 September 2003
PDF: 7 pages
Proc. SPIE 5149, Laser Applications in Medicine, Biology, and Environmental Science, (22 September 2003); doi: 10.1117/12.518686
Show Author Affiliations
Tiina I. Karu, Institute on Laser and Information Technologies (Russia)

Published in SPIE Proceedings Vol. 5149:
Laser Applications in Medicine, Biology, and Environmental Science
Gerhard Mueller; Valery V. Tuchin; Gennadii G. Matvienko; Christian Werner; Vladislav Ya. Panchenko, Editor(s)

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