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Proceedings Paper

Fluorescence diagnostics in oncological gynecology
Author(s): Ludmila A. Belyaeva; Leila V. Adamyan; Vladimir P. Kozachenko; Alexander A. Stratonnikov; Eugene F. Stranadko; Victor B. Loschenov
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Paper Abstract

The method of fluorescent diagnostics (FD) of tumors is a promising tool that may allow to increase sensitivity of tumor detection especially at initial stages. One of the most promising photosensitizers today is 5-aminolevulinic acid (5-ALA) that, actually, is not photosensitizer itself but precursor of protoporphyrin IX (PpIX). This paper deals with cancer diagnostics in gynecology by means of ALA-induced Pp IX laser-fluorescence spectroscopy. The tissue fluorescence spectra in vivo were studied in patients with various pathologies of ovaries, uterine and vulva after 5-aminolevulinic acid administration. It was shown that different pathologies varies in accumulation of Pp IX. Coefficient of fluorescence kf for normal tissue is not high, but exceptions are endometrium and mucous membrane of uterine tubes. Benign tumors of uterus and ovary have low values of kf, but polyps of endometrium exhibit high kf. Optical express-biopsy is important for diagnosis of ovarian cancer and micrometastatic spread. Coefficients of diagnostic contrast were determined for cancer of endometrium, cervical cancer, vulvar cancer.

Paper Details

Date Published: 13 October 2003
PDF: 6 pages
Proc. SPIE 5068, Saratov Fall Meeting 2002: Optical Technologies in Biophysics and Medicine IV, (13 October 2003); doi: 10.1117/12.518631
Show Author Affiliations
Ludmila A. Belyaeva, General Physics Institute (Russia)
Scientific Ctr. for Obstetrics, Gynecology, and Perinatology (Russia)
Leila V. Adamyan, Scientific Ctr. for Obstetrics, Gynecology, and Perinatology (Russia)
Vladimir P. Kozachenko, Cancer Research Ctr. (Russia)
Alexander A. Stratonnikov, General Physics Institute (Russia)
Eugene F. Stranadko, State Research Ctr. for Laser Medicine (Russia)
Victor B. Loschenov, General Physics Institute (Russia)


Published in SPIE Proceedings Vol. 5068:
Saratov Fall Meeting 2002: Optical Technologies in Biophysics and Medicine IV
Valery V. Tuchin, Editor(s)

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