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Proceedings Paper

The effects of visual fluorescence marking induced by 5-aminolevulinic acid for endoscopic diagnosis of urinary bladder cancer
Author(s): Dmitri I. Daniltchenko; Frank Koenig; Dietmar Schnorr; Alexander Valdman; Salman Al-Shukri; Stefan A. Loening
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Paper Abstract

During cystoscopy procedure, fluorescence diagnostics induced by 5-ALA improves visual detection of the bladder cancer. Macroscopic ALA-fluorescence allows visualizing of small flat tumors, carcinoma in situ, true neoplasm margins and dysplasias of the bladder. Following ALA instillation, cystoscopy has been performed under both standard and blue light illumination. Totally, 153 biopsies have been carried out at 53 patients with suspicion of bladder cancer. The results were compared to ALA-fluorescence data. In 13% of the patients, bladder cancer and dysplasia were found out in addition, due to red fluorescence. The sensitivity and specificity of ALA-fluorescence technique aggregated 96% and 52% respectively. The sensitivity and specificity of 5-ALA-fluorescent detection exceeded standard endoscopy under white light on 20%. The new method does not exclude a false positive and a false negative fluorescent luminescence. The ALA-based fluorescence detection system enhances the diagnosis of malignant/dysplastic bladder lesions significantly.

Paper Details

Date Published: 13 October 2003
PDF: 6 pages
Proc. SPIE 5068, Saratov Fall Meeting 2002: Optical Technologies in Biophysics and Medicine IV, (13 October 2003); doi: 10.1117/12.518629
Show Author Affiliations
Dmitri I. Daniltchenko, Charite (Germany)
Pavlov State Medical Univ. (Russia)
Frank Koenig, Charite (Germany)
Dietmar Schnorr, Charite (Germany)
Alexander Valdman, Pavlov State Medical Univ. (Russia)
Salman Al-Shukri, Pavlov State Medical Univ. (Russia)
Stefan A. Loening, Charite (Germany)

Published in SPIE Proceedings Vol. 5068:
Saratov Fall Meeting 2002: Optical Technologies in Biophysics and Medicine IV
Valery V. Tuchin, Editor(s)

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