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Proceedings Paper

Terahertz circular dichroism spectroscopy of biomolecules
Author(s): Jing Xu; Jhenny Galan; Gerald Ramian; Pavlos Savvidis; Anthony Scopatz; Robert R. Birge; S. James Allen; Kevin Plaxco
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Paper Abstract

Biopolymers such as proteins, DNA and RNA fold into large, macromolecular chiral structures. As charged macromolecules, they absorb strongly in the terahertz due to large-scale collective vibrational modes; as chiral objects, this absorption should be coupled with significant circular dichroism. Terahertz circular dichroism (TCD) is potentially important as a biospecific sensor, unobscured by spectral features related to abiological material. We have constructed atomistic simulations and elastic continuum models of TCD. These models estimate the magnitude of the TCD and the relation between TCD spectroscopic signatures (zero crossings) and the structure, charge distribution and mechanical properties of biomaterials. A broad band TCD spectrometer based on a polarizing interferometer is developed to explore TCD in biomolecules in aqueous solution. Preliminary results on TCD in lysozyme in water at several terahertz frequencies is presented.

Paper Details

Date Published: 27 February 2004
PDF: 8 pages
Proc. SPIE 5268, Chemical and Biological Standoff Detection, (27 February 2004); doi: 10.1117/12.518533
Show Author Affiliations
Jing Xu, Univ. of California/Santa Barbara (United States)
Jhenny Galan, Univ. of Connecticut (United States)
Gerald Ramian, Univ. of California/Santa Barbara (United States)
Pavlos Savvidis, Univ. of California/Santa Barbara (United States)
Anthony Scopatz, Univ. of California/Santa Barbara (United States)
Robert R. Birge, Univ. of Connecticut (United States)
S. James Allen, Univ. of California/Santa Barbara (United States)
Kevin Plaxco, Univ. of California/Santa Barbara (United States)

Published in SPIE Proceedings Vol. 5268:
Chemical and Biological Standoff Detection
James O. Jensen; Jean-Marc Theriault, Editor(s)

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