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Proceedings Paper

The potential of spectral imaging in the noninvasive diagnostics of tissue cancers and precancers
Author(s): Costas J. Balas
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Paper Abstract

A novel approach to the problem of non-invasive diagnostics is presented, which relay son a combiend optical and chemical excitation of the tissue, by employing white light and topical application of acetic acid solution, respecitvley. Acetic acid-tissue interaction results in a transient alteration in the light scattering properties of the abnormal tissue selectivity. A specially developed Spectral Imaging system was used for the in vivo spectral imaging and analysis of the tissue and for the measurement, as a function of both time and location, of the acetic acid-induced alterations in the tissue scattering properties. Modeling and fitting of the experimental data result in the calculation of the kinetic constants of the marker-tissue interaction process, and spatil distribution of whcih is visualized with the aid of a pseudocolor scale. Clinical evaluation of both methodology and technology in normal, precancerous and cancerous lesions of cervix show that the measured kinetic data contain specific information, which enables the differentiation between cancerous and non-cancerous lesions, as well as between dysplasias of different grade. The calculated map of the kinetic constants provides information for the spatial distribution of the lesion's grades, thus enabling the detection of incipient lesions and the precise localization and classification of pathologic tissue areas.

Paper Details

Date Published: 8 August 2003
PDF: 6 pages
Proc. SPIE 5123, Advanced Optical Devices, Technologies, and Medical Applications, (8 August 2003);
Show Author Affiliations
Costas J. Balas, Technical Univ. of Crete (Greece)
FORTH-Photonics Ltd. (United Kingdom)

Published in SPIE Proceedings Vol. 5123:
Advanced Optical Devices, Technologies, and Medical Applications
Janis Spigulis; Janis Teteris; Maris Ozolinsh; Andrejs Lusis, Editor(s)

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