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Proceedings Paper

Optical spectroscopic diagnosis of liver cancerous and normal blood serum
Author(s): Xiaozhou Li; Junxiu Lin; Jianhua Ding
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Paper Abstract

Laser induced human serum Raman spectra of liver cancer are measured. The spectra differences in serum from normal people and liver cancerous people are analyzed. There is obvious difference between the spectrum of liver cancer and that of normal people. For the typical spectrum of normal serum there are three sharp Raman peaks (A at approximately 1010 cm-1, at approximately 1160 cm-1, C at approximately 1525 cm-1) and relative intensity of Raman peak excited by 514.5 nm is higher than that excited by 488.0 nm. However, for the Raman spectrum of liver cancerous serum there are no peaks or very weak Raman peaks at the same positions of spectrum and intensity of Raman peak excited by 514.5 nm is lower than that excited by 488.0 nm. Results of more than two hundred case measurements show that clinical diagnostic accuracy is 92.86%. And then, the liver fibrosis is studied applying the technology of LIF. The experiment indicates that there is notable fluorescence difference between the abnormal and normal liver tissue, there is blue shift abnormal tissue in compare with normal liver tissue. These results have important reference values to explore the method of laser spectrum diagnosis.

Paper Details

Date Published: 1 August 2003
PDF: 6 pages
Proc. SPIE 4948, 25th International Congress on High-Speed Photography and Photonics, (1 August 2003); doi: 10.1117/12.516873
Show Author Affiliations
Xiaozhou Li, Dalian Univ. of Technology (China)
Liaoning Univ. (China)
Junxiu Lin, Liaoning Univ. (China)
Jianhua Ding, Liaoning Univ. (China)

Published in SPIE Proceedings Vol. 4948:
25th International Congress on High-Speed Photography and Photonics
Claude Cavailler; Graham P. Haddleton; Manfred Hugenschmidt, Editor(s)

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