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Proceedings Paper

Development of fiber-type surface plasmon resonance sensor for protein detection
Author(s): Woo Seok Ko; Se Baek Oh; Soo Hyun Kim; Yoon Keun Kwak
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Paper Abstract

As the mapping of the human genome has been completed, increasing emphasis is being placed on large-scale protein separation and identification methods to define the function of proteins and their associated genes. Within the last decade the sensing technique using the surface plasmon resonance(SPR) has received a great deal of attention and has become a leading technology for affinity-based biosensing. In this paper I report a novel design of SPR fiber optic sensing elements which allows developing highly miniaturized SPR probes. A fiber-optic chemical sensor is presented which utilizes surface plasmon resonance excitation. The sensing element of the fiber has been made by removing a section of the fiber cladding and symmetrically depositing a thin layer of highly reflecting metal onto the fiber core. A white light source is used to introduce a range of wavelengths into the fiber optic. Changes in the sensed parameters are determined by measuring the transmitted spectral intensity distribution. Therefore, when a protein layer is adsorbed on the metal surface, an increase in the refractive index occurs and can be detected. Based on theoretical analysis, the sensor structure is optimized to achieve the maximum sensitivity.

Paper Details

Date Published: 8 March 2004
PDF: 10 pages
Proc. SPIE 5272, Industrial and Highway Sensors Technology, (8 March 2004); doi: 10.1117/12.514682
Show Author Affiliations
Woo Seok Ko, Korea Advanced Institute of Science and Technology (South Korea)
Se Baek Oh, Korea Advanced Institute of Science and Technology (South Korea)
Soo Hyun Kim, Korea Advanced Institute of Science and Technology (South Korea)
Yoon Keun Kwak, Korea Advanced Institute of Science and Technology (South Korea)

Published in SPIE Proceedings Vol. 5272:
Industrial and Highway Sensors Technology
Brian Culshaw; Samuel David Crossley; Helmut E. Knee; Michael A. Marcus; John P. Dakin, Editor(s)

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