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Proceedings Paper

Estimation of prediagnostic duration of type 2 diabetes mellitus by lens autofluorometry
Author(s): Line Kessel; Charlotte Glumer; Michael Larsen M.D.
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Paper Abstract

Type 2 diabetes mellitus is a global epidemic with the number of affected subjects exceeding 4% of the adult population world-wide. Undiagnosed and untreated, the disease results in long-term complications such as myocardial infarction, stroke, and blindness. Treatment reduces the number and severity of long-term complications but treatment is often delayed by a time-lag of 10 years or more from the onset of disease to diagnosis. Earlier diagnosis can be achieved by systematic screening programs but the potential time won is unknown. The aim of the present study was to develop a mathematical model estimating the prediagnostic duration of type 2 diabetes mellitus using lens autofluorescence as an indicator of lifetime glycemic load. Fluorometry of the human is lens a quantitative measurement which is attractive because of the ease by which it can be performed. It is our hope that lens fluorometry will prove useful in estimating the prediagnostic duration of type 2 diabetes mellitus in population studies, a property of profound clinical relevance that is difficult to estimate by any other currently available method.

Paper Details

Date Published: 8 October 2003
PDF: 9 pages
Proc. SPIE 5141, Diagnostic Optical Spectroscopy in Biomedicine II, (8 October 2003); doi: 10.1117/12.500016
Show Author Affiliations
Line Kessel, Herlev Univ. Hospital (Denmark)
Charlotte Glumer, Steno Diabetes Ctr. (Denmark)
Copenhagen County Hospital (Denmark)
Michael Larsen M.D., Herlev Univ. Hospital (Denmark)

Published in SPIE Proceedings Vol. 5141:
Diagnostic Optical Spectroscopy in Biomedicine II
Georges A. Wagnieres, Editor(s)

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