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Proceedings Paper

Laser-induced fluorescence for the detection of esophageal and skin cancer
Author(s): Tuan Vo-Dinh; Masoud Panjehpour; Bergein F. Overholt M.D.; Clark E. Julius M.D.; Suzanne Overholt; Mary N. Phan
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Paper Abstract

Laser-induced fluorescence (LIF) is used for in-vivo cancer diagnosis of the esophagus and skin cancer. For esophageal measurements a fiberoptic probe inserted through an endoscope was used. Autofluorescence of normal and malignant tissues were measured directly on patient skin without requiring an endoscope. Measurement of the fluorescence signal from the tissue was performed using laser excitation at 410 nm. The methodology was applied to differentiate normal and malignant tumors of the esophagus and malignant skin lesions. The results of this LIF approach were compared with histopathology results of the biopsy samples and indicated excellent agreement in the classification of normal and malignant tumors for the samples investigated.

Paper Details

Date Published: 22 July 2003
PDF: 4 pages
Proc. SPIE 4958, Advanced Biomedical and Clinical Diagnostic Systems, (22 July 2003); doi: 10.1117/12.488678
Show Author Affiliations
Tuan Vo-Dinh, Oak Ridge National Lab. (United States)
Masoud Panjehpour, Thompson Cancer Survival Ctr. (United States)
Bergein F. Overholt M.D., Thompson Cancer Survival Ctr. (United States)
Clark E. Julius M.D., Univ. of Tennessee, Knoxville (United States)
Suzanne Overholt, Thompson Cancer Survival Ctr. (United States)
Mary N. Phan, Thompson Cancer Survival Ctr. (United States)

Published in SPIE Proceedings Vol. 4958:
Advanced Biomedical and Clinical Diagnostic Systems
Tuan Vo-Dinh; Warren S. Grundfest M.D.; David A. Benaron M.D.; Gerald E. Cohn, Editor(s)

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