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Proceedings Paper

Multifocal electroretinography: a functional laser injury metric
Author(s): Cheryl Dawn DiCarlo; Harry Zwick; Heike Rentmeister-Bryant; James M. Sankovich; Araceli Brown; Andres Grado; Ronald J. Dicks; Andre Akers; Bruce E. Stuck
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Paper Abstract

Currently there are no universally accepted functional diagnostics and treatments for laser eye injury. The multifocal electroretinogram (MERG) determines the function of several areas of the retina simultaneously. The objective of this research is to determine if the MERG is sensitive enough to provide a functional assessment of retinal laser lesions that correlates to established contrast sensitivity/visual acuity tests currently in use. The Visual-Evoked Response Imaging System (VERIS) ClinicTM, a MERG system with continuous visualization of the fundus, was used to record from normal rhesus monkeys. The MERG mapping of the rhesus monkeys was localized to the macula and centered on the foveal region. The recordings yielded three waveforms for each of the 103-recorded responses. A difference was seen in all of the waveform mean amplitudes with the human normal values being one and one-half times as large for the first, twice as large for the second and four times as large for the third waveform. This may be due to a much lower number of subjects for recording (5 Rhesus versus 48 human recordings) or the monkey retina may, in fact, produce lower amplitude retinal responses. This on-going project is expanding research to include the functional assessment of laser retinal injury through the use of the MERG with the intent of correlating the function to currently used behavioral metrics of the visual system.

Paper Details

Date Published: 20 June 2003
PDF: 7 pages
Proc. SPIE 4953, Laser and Noncoherent Light Ocular Effects: Epidemiology, Prevention, and Treatment III, (20 June 2003); doi: 10.1117/12.488647
Show Author Affiliations
Cheryl Dawn DiCarlo, Walter Reed Army Institute of Research (United States)
Harry Zwick, Walter Reed Army Institute of Research (United States)
Heike Rentmeister-Bryant, Naval Health Research Ctr. (United States)
James M. Sankovich, Walter Reed Army Institute of Research (United States)
Araceli Brown, Walter Reed Army Institute of Research (United States)
Andres Grado, Walter Reed Army Institute of Research (United States)
Ronald J. Dicks, Walter Reed Army Institute of Research (United States)
Andre Akers, Walter Reed Army Institute of Research (United States)
Bruce E. Stuck, Walter Reed Army Institute of Research (United States)


Published in SPIE Proceedings Vol. 4953:
Laser and Noncoherent Light Ocular Effects: Epidemiology, Prevention, and Treatment III
Bruce E. Stuck; Michael Belkin M.D., Editor(s)

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