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Proceedings Paper

Acute changes elicited by a nonablative wrinkle reduction laser: an ultrastructural study
Author(s): Tokuya Omi; Seiji Kawana; Shigeru Sato; Mitsuyoshi Honda
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Paper Abstract

Background and objective: Cosmeceuticals, chemical peels and collagen injections are used to rejuvenate skin, but none of those methods is effective or permanent. Recently, laser resurfacing has been found to be effective, but the incidence of side effects is relatively high. Last year, the non-ablative wrinkle reduction laser (N-Lite, ICN Photonics, UK) was developed, and there have been several reports about its clinical effectiveness. In this study, we have investigated ultrastructural changes elicited by N-Lite laser exposure. Material and methods: 6 adult volunteers were recruited for this study. They were treated with the N-Lite laser and a single 3-nm punch skin biopsy was obtained immediately after the inadiation, as well as 3 hours and 3 days later. These specimens were examined under an electron microscope. Results: Immediately after the laser exposure, capillary endothelial cells showed marked edema and inflamed mast cells were observed, but erythrocytes were intact. 3 hours after the laser therapy, capillary cells were stagnant and monocytes had moved out into the dermis. 3 days after the laser therapy, interstitial edema around the capillaries was observed, and elaunin fibres were also observed. Melanin granules were observed in fibroblasts and in capillaries. Conclusion: N-Lite laser irradiation leads to marked edema of endothelial cells and dermal coirnective tissue, although endothelial cell necrosis was not observed.

Paper Details

Date Published: 15 October 2002
PDF: 5 pages
Proc. SPIE 4903, Laser Florence 2001: A Window on the Laser Medicine World, (15 October 2002); doi: 10.1117/12.486611
Show Author Affiliations
Tokuya Omi, Queen's Square Medical Ctr. and Nippon Medical School (Japan)
Seiji Kawana, Nippon Medical School (Japan)
Shigeru Sato, Nippon Medical School (Japan)
Mitsuyoshi Honda, Queen's Square Medical Ctr. (Japan)

Published in SPIE Proceedings Vol. 4903:
Laser Florence 2001: A Window on the Laser Medicine World
Leonardo Longo; Alfons G. Hofstetter; Mihail-Lucian Pascu; Wilhelm R. A. Waidelich, Editor(s)

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