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Nonablative remodeling: a 14-month clinical ultrasound-imaging profilometric evaluation of a 1540-nm Er:Glass laser
Author(s): Nathalie Fournier; Serge Dahan; Gilbert Barneon; Celine Rouvrais; Stephane Diridollou; Jean-Michel Lagarde; Serge R. Mordon
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Paper Abstract

Background: Non-ablative remodeling has been recently proposed as a new anti-ageing treatment with no downtime. Objective: To evaluate the efficacy and safety of non-ablative skin remodeling with a 1540 nm Er:Glass laser and contact cooling on pen-oral and pen-orbital rhytids at 14 months follow up. Methods: 42 female patients (mean age: 47 years), Fitzpatrick skin types I -IV were treated five times at 6 weeks intervals, and checked 6 months after the last treatment . Patients were evaluated using clinical data, patients satisfaction (scale 1 to 4), digital pictures, ultrasound imaging and profilometry data from silicone imprints in order to quantify the degree of improvement. Results: All subjects reported an improvement in the quality and visual aspect of their skin at 6 months (mean patient's satisfaction : 3,06/4) and they noticed that it was very similar at 14 months after enrollment (mean patient's satisfaction: 2.9/4) . This was confirmed by a 43.2% reduction ofanisotropy (p<O.OO1) six weeks after the 4th treatment, and even 49.5 % reduction 6 weeks after the 5th treatment. Ultrasound imaging demonstrated a 17% increase of the dermis thickness (p<O.OO5) 1 month after the 3rd freatment and still 1 1% increase 6 months after the last treatment. A lack of immediate or late adverse effects was noted at all stages ofthe procedure. Conclusion: This study demonstrated that irradiation with a 1540nm Er:Glass laser emitting in a pulsed mode and coupled with an efficient cooling system , increases dermis thickness, reduces the anisotropy ofthe skin and finally improves clinical aspects. The lack of adverse effects confirmed that all this procedure was safe.

Paper Details

Date Published: 15 October 2002
PDF: 13 pages
Proc. SPIE 4903, Laser Florence 2001: A Window on the Laser Medicine World, (15 October 2002); doi: 10.1117/12.486605
Show Author Affiliations
Nathalie Fournier, Ctr. Commercial La Croisée (France)
Serge Dahan, Clinique St. Jean du Languedoc (France)
Gilbert Barneon, Parc Euromédicine (France)
Celine Rouvrais, Institute de Recherche Pierre Fabre (France)
Stephane Diridollou, Institute de Recherche Pierre Fabre (France)
Jean-Michel Lagarde, Institute de Recherche Pierre Fabre (France)
Serge R. Mordon, INSERM (France)

Published in SPIE Proceedings Vol. 4903:
Laser Florence 2001: A Window on the Laser Medicine World
Leonardo Longo; Alfons G. Hofstetter; Mihail-Lucian Pascu; Wilhelm R. A. Waidelich, Editor(s)

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