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Proceedings Paper • Open Access

Development of SH-SAW sensors for measurement of the properties of protein solutions
Author(s): Yongrae Roh; Yongjun Kwon; Kyungho Kim; Kwangnak Koh; Jaeho Kim

Paper Abstract

We developed new surface acoustic wave (SAW) sensors to measure the properties of protein solutions applying a particular organic thin film on the delay line of transverse type SAW devices. Each delay line is configured as an oscillator. The delay line for a sensing channel is coated with a gold film on which an antibody layer is immobilized by protein A. The sensing delay line selectively adsorbs antigens when exposed to a protein solution, which results in phase delay changes due to the mass loading effects induced by the adsorbed antigens. The other delay line is uncoated for use as a stable reference. The relative change in the frequency of the two oscillators is monitored to measure the concentration of the antigens. Sensor properties investigated include selectivity, sensitivity, response time and stability in response to the antigen concentration as well as the viscosity and electrical conductivity of the protein solution.

Paper Details

Date Published: 22 July 2003
PDF: 8 pages
Proc. SPIE 5055, Smart Structures and Materials 2003: Smart Electronics, MEMS, BioMEMS, and Nanotechnology, (22 July 2003); doi: 10.1117/12.483576
Show Author Affiliations
Yongrae Roh, Kyungpook National Univ. (South Korea)
Yongjun Kwon, Kyungpook National Univ. (South Korea)
Kyungho Kim, Samsung Advanced Institute of Technology (South Korea)
Kwangnak Koh, Kyungpook National Univ. (South Korea)
Jaeho Kim, Ajou Univ. (South Korea)

Published in SPIE Proceedings Vol. 5055:
Smart Structures and Materials 2003: Smart Electronics, MEMS, BioMEMS, and Nanotechnology
Vijay K. Varadan; Laszlo B. Kish, Editor(s)

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